Saranya JaiKumar Instagram – We discuss today about a strong link between Gum Disease and Alzheimer’s.
Periodontitis, a chronic bacterial infection of the gums, is often caused by Porphyromonas gingivalis (P. gingivalis), a key periodontal pathogen. This bacterium and its toxic enzymes, known as gingipains, can enter the bloodstream and travel to the brain, triggering an immune response.
One of the hallmarks of Alzheimer’s disease is the buildup of beta-amyloid plaques, which disrupt neural function. Recent studies suggest that gingipains from P. gingivalis can stimulate the production of beta-amyloid as a defense mechanism against infection. However, instead of protecting the brain, beta-amyloid aggregates and contributes to neuroinflammation, neuronal damage, and cognitive decline.
Furthermore, chronic inflammation caused by untreated gum disease may exacerbate Alzheimer’s progression by increasing levels of inflammatory cytokines, which promote neurodegeneration. Some research even suggests that P. gingivalis DNA and toxins have been found in the brains of Alzheimer’s patients, reinforcing the idea that oral health plays a crucial role in brain health.
Maintaining good oral hygiene and regular dental check-ups could potentially reduce the risk of gum disease-related inflammation and its possible contribution to Alzheimer’s pathology.
Saree : @santhanam_handloom_silks | Posted on 23/Mar/2025 07:30:53
